Abstract: Objective To explore the effect of psychological intervention on the curative efficacy, compliance and psychological status of patients with systemic lupus erythematosus (SLE). Methods Total 64 SLE patients in our hospital between June, 2015 and December, 2016 were divided into psychological intervention group and control group. The control group received medical routine nursing, while the other group received psychological intervention. Before and after the treatment, SLE disease activity score (SLEDAI), Hamilton anxiety scale (HAMA) and depression scale (HAMD) scores, and the Pittsburgh sleep quality index scale (PSQI) were compared between the two groups. Results HAMA (12.14±3.68 vs. 9.29±3.43, P<0.001), HAMD (11.32±3.86 vs. 9.70±3.01, P=0.04), the SLEDAI score (10.29±4.60 vs. 9.46±5.56, P<0.001) of psychological intervention group were lower than those of the control group, the difference was statistically significant; The treatment adherence was higher, and the SLEDAI and disease recurrence rates were lower than those in the control group. The score of the control group was not statistically significant. After 6 months of treatment, the treatment compliance in the psychological intervention group was higher than that in the control group (χ²=4.947, P=0.025); the SLEDAI (t=-3.410, P=0.039) and disease recurrence rate (χ²=4.433, P=0.032) of the psychological intervention group was lower than those of the control group, the difference was statistically significant. C3, C4 and ESR, CEP were no statistically significant different between the two groups. Conclusion The psychological intervention can relieve the anxiety and depressed mood, improve the treatment compliance of patients, promote the remission and reduce the recurrence, improve the therapeutic effect, prognosis and QOL of patients with SLE.