胎盘生长因子和血红素加氧酶-1在子痫前期发病中的作用

吴红莲; 陈艳; 黄志华; 闫贵贞; 夏伟兰; 王双虎

doi:10.16766/j.cnki.issn.1674-4152.000506

胎盘生长因子和血红素加氧酶-1在子痫前期发病中的作用

doi: 10.16766/j.cnki.issn.1674-4152.000506

1. 丽水市人民医院(温州医科大学附属第六医院)妇产科, 浙江丽水 323000;
2. 丽水市人民医院(温州医科大学附属第六医院)临床药学科

基金项目:

2015年浙江省医药卫生一般研究计划(2015KYA230)

详细信息

通讯作者:
吴红莲,E-mail:lgnai1100@qq.com

中图分类号: R714.245;R446.61
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出版历程
- 收稿日期: 2017-11-23
- 网络出版日期: 2022-08-06

The role of human placental growth factor and human heme oxygenase-1 in the pathogenesis of preeclampsia

Department of Obstetrics and Gynecology, People's Hospital of Lishui City, Lishui, Zhejiang 323000, China

摘要

摘要: 目的探讨胎盘生长因子和血红素加氧酶-1在子痫前期发病中的作用。方法选择2014年1月-2017年1月丽水市人民医院产科轻度子痫前期孕妇90例为轻度子痫前期组,90例重度子痫前期孕妇为重度子痫前期组,90例健康孕妇为对照组。采用酶联免疫吸附试验(ELISA)法测定血清胎盘生长因子和血红素加氧酶-1水平。结果 3组孕妇24小时尿蛋白、平均动脉压、血清胎盘生长因子、血红素加氧酶-1水平差异均有统计学意义(P<0.05)。轻度子痫前期组和重度子痫前期组24小时尿蛋白和平均动脉压均高于对照组(P<0.05),重度子痫前期组24小时尿蛋白和平均动脉压高于轻度子痫前期组(P<0.05)。轻度子痫前期组和重度子痫前期组血清胎盘生长因子、血红素加氧酶-1水平均低于对照组(均P<0.05),重度子痫前期组血清胎盘生长因子和血红素加氧酶-1水平均低于轻度子痫前期组(均P<0.05)。子痫前期孕妇血清胎盘生长因子、血红素加氧酶-1水平与24小时尿蛋白、平均动脉压均呈负相关(均P<0.05)。子痫前期孕妇血清胎盘生长因子与血清血红素加氧酶-1水平呈正相关(均P<0.05)。结论子痫前期孕妇血清胎盘生长因子与血清血红素加氧酶-1水平降低,血清胎盘生长因子与血清血红素加氧酶-1水平与子痫前期的严重程度有关,两者可能在子痫前期的发病过程中相互作用,共同参与子痫前期的发生发展。
- 胎盘生长因子 /
- 血红素加氧酶-1 /
- 子痫前期
Abstract: Objective To investigate the role of human placental growth factor and human heme oxygenase-1 in the pathogenesis of preeclampsia. Methods Ninety cases of mild preeclampsia pregnant women were selected as mild preeclampsia group 90 cases of severe preeclampsia pregnant women were selected as severe preeclampsia group and 90 healthy pregnant women were selected as control group from January, 2014 to January, 2017 in Lishui City People's Hospital obstetric. The serum levels of placental growth factor and heme oxygenase-1 were determined by enzyme-linked immunosorbent assay (ELISA). Results The levels of 24 h urinary protein mean arterial pressure serum placental growth factor and heme oxygenase-1 among the three groups were statistically significant (P<0.05). The 24 h urinary protein and mean arterial pressure in mild preeclampsia group and severe preeclampsia group were significantly higher than that in control group (P<0.05). The 24 h urinary protein and mean arterial pressure in severe preeclampsia group were significantly higher than that in mild preeclampsia group (P<0.05). The levels of serum placental growth factor and heme oxygenase-1 in mild preeclampsia group and severe preeclampsia group were lower than those in control group (P<0.05). The levels of serum placental growth factor and heme oxygenase-1 in severe preeclampsia group were lower than those in mild preeclampsia group (P<0.05). The level of serum placental growth factor and heme oxygenase-1 in pregnant women with preeclampsia were negatively correlated with 24 h urinary protein and mean arterial pressure (P<0.05). There was positive correlation between serum placental growth factor and serum heme oxygenase-1 in pregnant women with preeclampsia (P<0.05). Conclusion Preeclampsia maternal serum placental growth factor and serum heme oxygenase-1 levels decrease.The serum placental growth factor and serum heme oxygenase-1 level are related to the severity of preeclampsia both may interact during the onset of preeclampsiainvolved together the development of preeclampsia.
- Placental growth factor /
- Heme oxygenase-1 /
- Preeclampsia