Abstract: Objective To observe the clinical effect of Manpenxiaoyan decoction combined with metronidazole and levofloxacin in the treatment of endometritis, and effect on the level of inflammatory factors in patients. Methods Total 190 cases of endometritis patients were studied, and all the patients were randomly divided into the study group (95 cases) and the control group (95 cases). The patients in the control group were treated with metronidazole and levofloxacin intravenously, and the patients in the study group were increased the Manpenxiaoyan decoction on the basis of the control group. The adverse reactions during treatment were observed, the time of symptom disappearance was recorded, the curative effect level was evaluated, and the recurrence of inflammation within 1 years was counted. Results The serum MMP-9 and IL-4 levels of the study group were significantly lower than those of the control group after treatment, while IL-2 and IL-10 levels were significantly higher than those of the control group (P<0.05). The time of pelvic area pain and leucorrhea disappeared in the study group[(9.31±2.63)d and (13.72±3.27)d] were significantly shorter than those in the control group[(14.28±3.51) d and (20.43±4.16)d], P<0.05. The total effective rate of the treatment of patients with endometritis in the study group (94.74%) was significantly higher than that of the control group (85.26%, χ²=4.737, P=0.030). Within 1 years after treatment, the recurrence rate of endometritis in the study group (11.58%) was not significantly different from that in the control group (24.21%, χ²=5.158, P=0.023). During the treatment, the overall incidence of adverse drug reactions (10.53%) in the study group was not significantly different from that in the control group (7.37%, χ²=0.581, P=0.446). Conclusion Compared with simple western medicine, Manpenxiaoyan decoction combined with metronidazole and levofloxacin can significantly inhibit the inflammation of the endometrium, shorten the recovery cycle, improve the level of curative effect, prevent the recurrence of the inflammation, and do not increase the adverse drug reaction.