Abstract: Objective To investigate the effect of Fuyuan Huoxue Decoction Combined with western medicine on preventing hemorrhage after mammotome operation and its effect on postoperative pain, so as to improve the clinical effect of benign breast swelling. Methods In this study, 80 women with mammotome breast nodules in our hospital during the period of June, 2016 to October, 2017 were selected as the subjects. According to the simple randomization group (1:1), they were divided into the control group and the observation group, and the two groups were 40 cases each. The control group was given the elastic bandage pressure thin wrapping 48 h treatment and the static drip of hemostatic medicine. On the basis of the control group, the observation group was treated with 3D combined with Fuyuan Huoxue Decoction. The operation time, the amount of bleeding, the time of hospitalization and the cost of the two groups were compared, and the postoperative pain visual analogue score (VAS) and the related complications were observed. Results Two groups of patients were successfully completed surgery, no withdrawal case. The amount of operation bleeding[(5.1±1.5) ml], hospital days[(3.4±1.3) days] and hospitalization expenses[(8 970.2±921.3) yuan] were lower than that of the control group[(6.8±1.7) ml], hospitalization days[(4.1±1.1) days] and[(9 452.6±845.2) yuan], and the difference was statistically significant (P<0.05). The postoperative hematoma rate 2.50% (1/40) was significantly lower in the observation group. The difference was statistically significant in the control group 22.50% (9/40), and the difference was statistically significant (P<0.05). The VAS scores of 2D and 3D[(3.2±1.0) and (2.5±0.9)] in the observation group were lower than those of the control group[(3.8 ±1.2) and (3.1± 1.1)] respectively, and the difference was statistically significant (P<0.05). Conclusion Fuyuan Huoxue Decoction can help reduce the risk of bleeding and complication of hematoma, reduce the patient's physical pain and hospitalization expenses, and the clinical application value is remarkable.