Abstract: Objective This article aims to investigate the clinical effects of the WeChat follow-up care to alleviate the negative emotions in adult patients with epilepsy and to strengthen the care of patients with family members. Methods A total of 100 patients with epilepsy in our emergency department and neurology outpatient department from 2015 to 2017 were divided into control group and observation group based on random number method, with 50 cases in each group. Patients in the control group were followed up by phone and outpatient clinic while in the observation group, by telephone and out-patient follow-up, plus WeChat follow-up. On the patient's enrollment day, 1 month after hospital discharge, 3 months, the patients took anxiety assessment form(SAS) prepared by ZUNG, patients and their families' knowledge about disease questionnaire, family members nursing ability, patients satisfaction with the work of health care workers. Results There was no statistically significant significance (P>0.05) on the above-mentioned data. However, after 1 month and 3 months of follow-up with WeChat, the prevalence of SAS, relatives ‘ability to take care of patients, level of awareness and patients’ satisfaction with the work of medical staff were significantly better than those of the control group, and the difference was statistically significant(P<0.05). Conclusion WeChat follow-up care in improving the bad mood in adults with epilepsy and family members have a significant clinical effect, which is worth in the major medical institutions for a wide range of implementation and use.