Abstract: Objective To observe the clinical efficacy and nursing of Mecobalamine Combined with hemoperfusion in uremic peripheral neuropathy. Methods 120 patients with uremic peripheral neuropathy admitted to Luzhou People's Hospital from March, 2016 to March, 2017. Were randomly divided into 2 group,The control group was given 1 hemoperfusion every week on the basis of 2 routine hemodialysis once a week. The experimental group was given subcutaneous injection of mecobalamine twice a week, 0.5 ml/time, On the basis of the treatment of the control group. Check the changes of nerve reflex and sensory nerve conduction velocity. During the treatment period, patients were given hemoperfusion, daily nursing and psychological nursing. Results After 8 weeks of treatment, the total effective rate of the treatment group was 90.00%. The clinical symptoms such as limb pain, sensory disturbance, numbness and restless leg syndrome were significantly improved. The respective effective rates were 89.47%, 80.00%, 85.71% and 87.50% respectively. The disappearance of nerve reflex (upper limb tendon reflex disappearance, knee limb tendon reflex disappearance) was significantly alleviated, and the nerve conduction speed (median nerve, common peroneal nerve, tibial nerve) was significantly faster than that of the control group. No blood coagulation, hemolysis, allergy, bleeding, bleeding, skin damage and other conditions were found during blood perfusion. Conclusion Uremia patients are treated with hemodialysis for a long time. Hemoperfusion on the basis of dialysis can purify the blood more fully. The application of mecobalamine can repair injured nerves and promote the excretion of toxins, which can alleviate the condition of uremic peripheral neuropathy in patients.Mecobalamine Combined with hemoperfusion can effectively improve peripheral neuropathy.