Abstract: Objective To investigate the expressions of TFF3 and PDGFR in human Gastric carcinoma and analyze the relationship between them and tumor clinicopathological features as well as the role of TFF3 and PDGFR in the metastasis and invasion. Methods The expression of TFF3 and PDGFR in 60 cases of gastric cancer and corresponding adjacent non tumor tissue were detected by immunohistochemistry,which were from July, 2010 to June, 2011 in the First Affiliated Hospital of Bengbu Medical College, and then the relationship between TFF3, PDGFR expressions and clinicopathology were analyzed. Results The expression of TFF3 was located in cell membrane and cytoplasm, a significant difference was observed between gastric carcinoma and in adjacent non tumor tissue(P<0.05). The expression of TFF 3 was related to tumor TNM stage(P=0.007) and lymph node metastasis(P=0.003). The expression of PDGFR was located in cytoplasm, a significant difference was observed between the groups(P<0.05). The expression of PDGFR was related to TNM stage(P=0.001), lymph node metastasis(P=0.010) and serosal layer breakthrough(P=0.004). TFF 3 expression was positive correlated with PDGFR(r=0.348,P=0.007). Conclusion There is statistically positive correlation between TFF 3 and PDGFR expression, which indicates that they may participate in the occurrence and development of gastric carcinoma. Combination of TFF3 and PDGFR detection may be helpful to evaluate the capability of the tumor invasion and diversion of gastric carcinoma.