Abstract: Objective To evaluate the prognostic value of liver-specific multiple organ failure (MOF) score in patients with alcoholic liver cirrhosis. Methods From January, 2012 to June, 2017, 126 patients with alcoholic liver cirrhosis and liver failure admitted to the Second hospital of Ningbo were retrospectively collected. The patients were followed up for one year. According to whether the patients died within one year or not, the patients were divided into a death group (n=34) and a survival group (n=92). The differences of CLIF-COFs, APACHE Ⅱ, SOFA, end-stage liver disease model-sodium and end-stage liver disease model scores between the two groups were analyzed. The ROC curve was used to analyze the value of these indexes in the diagnosis of death in alcoholic liver cirrhosis within one year. Results When compared with the survival group, the CLIF-COFs in the death group were significantly higher (11.35±3.15 vs. 6.46±2.61, P<0.001); the APACHE Ⅱ score was significantly higher (15.85±6.37 vs. 12.01±5.65, P=0.001); the SOFA score was significantly higher (6.62±1.74 vs. 4.22±1.63, P<0.001); the sodium score in the end-stage liver disease model was significantly higher (25.41±4.29 vs. 21.25±4.07, P<0.001); the score of end-stage liver disease model was significantly higher (22.94±5.07 vs. 17.88±6.20, P<0.001); Maddery score increased significantly (63.37±18.47 vs. 49.82±19.67, P=0.001). CLIF-COFs, APACHE Ⅱ score, SOFA score, end-stage liver disease model-sodium score, end-stage liver disease model score and Maddery score were 0.875, 0.672, 0.831, 0.751 and 0.728 under the diagnostic curve of death in alcoholic cirrhosis patients within one year, respectively, of which CLIF-COFs was the highest[0.875 (0.811-0.939), P<0.001]. Conclusion Liver-specific multiple organ failure score is valuable in predicting the prognosis of alcoholic liver cirrhosis, and can be further applied.