Abstract: Objective To observe the value of "Bian Que Flying Rescue" system for acute ST segment elevation myocardial infarction (STEMI) patients by observing change of myocardial reperfusion time and prognosis with this system. Methods Total 70 STEMI patients who were transported to Wuxi Second People's Hospital by "Bian Que Flying Rescue" system between January, 2015 to January, 2016 were selected as Bian Que Flying Rescue Group, meanwhile, 70 STEMI patients who were transported before the system operating assigned into Control Group. All of patients were accepted emergency PCI. Features like first medical contact to balloon (FMC2B) time, door to balloon (D2B) time, average hospitalization days, and LVEF were collected. All patients were followed up for 6 months to observe the prognosis. Results Compared with Control Group, FMC2B time and D2B time were significantly shorter and attainment rates were higher, a downward trend had shown in hospitalization days and LVEF was improved in Bian Que Flying Rescue Group, and Kaplan-Meier survival analysis found that the non-MACE survival rate was significantly higher in Bian Que Flying Rescue group than control group, Logistic regression analysis revealed that FMC2B time>120 min and D2B time>90 min were independent risk factor for MACE, the odds ratio (OR) (95% CI) were 2.64 (0.75-9.33) and 1.01 (0.99-1.03); all of P value were less than 0.05. Conclusion "Bian Que Flying Rescue" system can significantly cut down the treatment delay, improve clinical prognosis for the patients with STEMI.