Abstract: Objective To investigate the effect of real-time dynamic insulin pump on blood glucose monitoring in patients with type 2 diabetes mellitus. Methods From January, 2013 to December, 2016, 210 patients with type 2 diabetes were selected as the subjects. All the patients were divided into observation group (152 cases, Medtronic monitoring blood sugar) and control group (58 cases, blood sugar was monitored by traditional method). The indicator for further observation included the blood glucose data of patients monitored by different monitoring methods; the monitoring of blood glucose by Medtronic on first days and third days, the tolerance of patients during monitoring blood glucose. Results During the monitoring of blood glucose, the blood sugar changes in the two groups were all controlled, and the dynamic blood glucose curve showed that the blood glucose data value gradually stabilized. The time of blood glucose reaching the standard in the observation group was (3.52±1.40)days and that in the control group was (6.03±1.51) days. The difference between the two groups was significant (t=10.985, P<0.05). The area under the blood glucose curve of observation group was (88.43±11.15) and that of control group was (99.48±15.26). The difference between the two groups was statistically significant (t=5.026, P<0.001). While the observation group found that 4 patients had low blood sugar in the next morning and adjusted the insulin dosage accordingly. The number of hyperglycemia monitoring for third days was (25.60±15.88) times, compared with first days (40.33±25.17) decreased significantly (t=6.102, P<0.001). The Medtronic insulin pump was well tolerated in the observation group, while in the control group, 70.69% patients (41/58) were found in the subcutaneous of insulin infusion, and there were 3 cases in the control group. Conclusion Medtronic can monitor the blood glucose level of type 2 diabetic patients in real time and realize the function of insulin infusion in the islet pump. The immediate monitoring of the continuous 72 h of the blood glucose level in the patients can help to find the early warning of hyperglycemia and the real time fluctuation of blood sugar so as to facilitate the clinical treatment and adjust timely the insulin regimen and dosage during the monitoring period of the blood sugar.