Abstract: Objective To analyze the level of serum anti-CCP antibody in 153 elderly patients with rheumatoid arthritis and evaluate the application value of anti-CCP antibody detection in elderly patients with rheumatoid arthritis, and to provide reference for clinical diagnosis of this disease. Methods Total 153 elderly patients with rheumatoid arthritis admitted to our department from June, 2014 to June, 2018 were selected as the study group. Total 153 patients with other rheumatoid arthritis and 153 patients with routine physical examination in the physical examination center were selected as the control group and the healthy group, respectively.The serum anti-CCP antibody level was detected by the test method, and the results were compared, to evaluate the clinical value of serum anti-CCP antibody in the detection of rheumatoid arthritis. Results The levels of serum anti-CCP antibodies in the study group were significantly higher than those in the control group and the healthy group (P<0.05). The accuracy,sensitivity,specificity,positive predictive value and negative predictive value of anti-CCP antibody were 77.8%, 65.3%, 84.9%, 71.2% and 81.0%, respectively.The number of joint swelling,joint tenderness,DAS28 score and invasive bone destruction rate in anti-CCP positive group are higher than those in anti-CCP negative group (P<0.05). Conclusion The serum anti-CCP antibody level and positive detection rate of elderly patients with rheumatoid arthritis are significantly higher than those of other rheumatoid patients and healthy people.