Abstract: Objective To investigate the correlation between the expression of inflammatory related factors and HMGB1 protein in patients with unexplained recurrent early abortion. Methods From February, 2013 to July, 2017, 172 cases of pregnant women with unexplained recurrent early abortion were selected as abortion group, and the other pregnant women with not unexplained recurrent early abortion were selected as the control group accorded to the 1:1 matching principle, the serum inflammation related factors and the expression of HMGB1 in the two groups were detected and were given correlation analysis. Results The serum IL-6, TNF-α and HMGB1 levels in the abortion group were (49.22±10.39)pg/L, (82.49±10.11)pg/L and (99.02±21.49)ng/ml that were significantly higher than the control group of (27.33±9.82)pg/L, (30.19±6.88)pg/L and (47.99±10.53)ng/ml (P<0.05). Pearson analysis showed that the serum IL-6, TNF-α were positive correlation to the HMGB1 in the abortion group(r=0.562, 0.672, P<0.05). Multivariate Logistic regression analysis showed that IL-6, TNF-α and HMGB1 were the main risk factors of unexplained early recurrent spontaneous abortion (P<0.05). Conclusion The inflammatory factors IL-6, TNF-α and HMGB1 in the unexplained recurrent early abortion are showed high expression, and can influence each other, they are independent risk factors of spontaneous abortion.