Abstract: Objective A comprehensive analysis on the effect of the general practitioner-led (GP-led) campus health management. Methods We established electronic health record (HER) for 7 875 students from Longbai District, who come from primary and secondary schools in 2015, and performed statistical analysis on Health Card and accompanying visitors. Results Student EHR coverage:100%; standard disease control:98.96%. Statistic significance (χ²=645.551, P<0.001; χ²=398.089, P<0.001, respectively) has been reached through comparing the effects of accumulative interventions from different diseases, as well as the latest intervention. Meanwhile, independent sample t test and rank sum test has concluded that neither of these interventions has made statistical significance on disease control when exerting to the same disease. In addition, logistic regression analysis has suggested that educated services, campus health advisory, family attention affect disease control with a statistical significance[OR=0.112 (0.086, 0.367), P<0.001; OR=6.231 (3.086, 10.300), P<0.001; OR=2.564 (1.665, 10.675), P<0.001, respectively]. Conclusion The approach of GP-led campus health management had regulated the disease control rate so that it improved the health administration among students. It has also spread the modern concept of knowledge-attitude-belief into health management among teenagers, which would propel the development of GP practice and general communal services.