Abstract: Many studies have shown that the clinical symptoms of cardiovascular diseases overlap with the symptoms of mental and psychological diseases in a considerable part, that is, cardiovascular diseases often coexist with mental and psychological diseases, which makes it difficult for a single treatment to achieve good results, and causing the concern by medical community in recent years for both heart and psychological, that is "comorbidity of heart disease and mental illness". However, traditional Chinese medicine advocates the concept of "comorbidity of heart disease and mental illness" from the perspective of the whole. It holds that the shape and function of the heart are closely related to psychology, and is closer to the current concept of "comorbidity of heart disease and mental illness". However, most clinical cardiologists do not have the ability to diagnose and treat heart disease and mental illness because of the limitations of their specialties. On the other hand, due to the existing psychiatric drug adverse reactions, and most patients are psychologically resistant to psychiatric treatment, which makes the " heart disease and mental illness " in the clinical diagnosis and treatment of difficulties. In order to explore the clinical characteristics of "comorbidity of heart disease and mental illness", some epidemiologists in China have carried out epidemiological studies. The results support the view that cardiovascular disease is accompanied by psychological disorders, and confirm the real situation of "heart disease and mental illness ". In the clinical diagnosis and treatment of this type of disease, there are great differences between traditional Chinese medicine and Western medicine in the treatment of ideas and ideas. This difference is reflected in the concept and methods of diagnosis and treatment of multiple differences, how to integrate the advantages of traditional Chinese and Western medicine in the treatment of "comorbidity of heart disease and mental illness" to improve clinical diagnosis and treatment capacity and accuracy is the important problems to be solved. In view of the clinical progress in the diagnosis and treatment of "comorbidity of heart disease and mental illness", this article will review the ideas and specific measures of Chinese and Western medicine for "heart disease and mental illness " in order to provide more reference for clinical practice.