Abstract: Objective To observe and evaluate the application of the whole process network management mode in stroke rehabilitation. Methods From November, 2016 to January, 2018, 100 patients who met the criteria of stroke in Wuhu City and its surrounding areas were selected for graded rehabilitation. The patients were randomly divided into experimental group and control group, with 50 patients in each group. The experimental group was rehabilitated by the management mode of "whole process network". In the control group, the management mode of "family tradition" was used for rehabilitation. Patients in both groups were evaluated 1 day after enrollment, 1 month and 3 months after discharge. Frenchay activity scale was used to assess the self-care ability of daily life; the special quality of life scale for stroke (SS-QQL) was used to evaluate the patients' satisfaction with quality of life; and the social support scale (SSQ) was used to assess the degree of social support of the patients. Results Compared with control group, scores of Frenchay activity scale, SS-QOL scale and SSQ scale of the experimental group at 1 month (F_Frenchay=12.563, F_SS-QOL=23.738, F_SSQ=85.388) and 3 months (F_Frenchay=37.180, F_SS-QOL=60.889, F_SSQ=192.023) after discharge were significantly higher (P<0.05). Compared with experimental group before test, scores of Frenchay activity scale, SS-QOL scale and SSQ scale of the experimental group at discharge1 month after discharge and 3 months after discharge were significantly higher (P<0.05). Conclusion The "whole process network" management mode can improve the daily living self-care ability, quality of life satisfaction and social support status of patients with stroke rehabilitation during hospitalization and after discharge. It further promotes the three-level diagnosis and treatment management of stroke rehabilitation in Anhui Province to the greatest extent.