Abstract: Objective To explore the clinical effect of Epley manual reduction combined with acupuncture in the treatment of posterior semicircular canal benign paroxysmal positional vertigo (PC-BPPV) patients, and the remission rate and remission time of vertigo symptoms. Methods From April, 2017 to March, 2018, 86 PC-BPPV patients in the department of neurology of Xuzhou hospital of traditional Chinese medicine were selected as study objects, and 86 patients were randomly divided into the treatment group and the control group, each with 43 patients. The two groups were treated with Epley manipulation for reduction. In the treatment group, rapid acupuncture was added on the basis of Epley manipulation, and acupoints such as Taiyang, Yintang, Baihui, Sishencong and Zusanli were treated. The control group was treated with Epley reduction. The two groups were treated once every other day and 6 times were the course of treatment. This observation was made immediately after the first treatment to compare the rate of delay of vertigo symptoms and the time of remission of vertigo symptoms. The cure rates, total effective rates were compared after 3 months. Recurrence rates were compared after 6 months. Results After the first treatment, the remission rate of vertigo symptoms was 93.02%, the average time of remission of vertigo symptoms was 8.5 minutes, the cure rate was 83.72% after 3 months, and the total effective rate was 97.67%. The relapse rate after June was 11.62%. The remission rate of vertigo symptoms was 74.41% in the control group after the first treatment, and the average remission time of vertigo symptoms was 22.5 minutes. the cure rate was 69.77% after march, the total effective rate was 79.06%, and the recurrence rate was 37.20% after June. There were significant statistical differences in all the groups (P<0.05). Conclusion Epley manipulation manual reduction combined with acupuncture can rapidly improve the symptoms of vertigo in PC-BPPV patients with high cure rate and low recurrence, which is considered excellent single Epley manipulation treatment.