Abstract: Objective To evaluate the effect of new methods in improving the oropharyngeal dryness of patients during nasal tamponade. Methods From December, 2016 to May, 2017, 118 patients who underwent general anesthesia under otolaryngology and underwent nasal tamponade were randomly divided into control group and the observation group, with 59 patients in each group. The control group implemented the traditional routine nursing method, and the observation group used the improved oropharyngeal humidification method, i.e., the conventional oxygen-absorbing device was not humidified, but cut the two oxygen absorbing tubes first, and then connected the two cut oxygen absorbing tubes and the atomizer connecting tube with the infusion tee. One end is connected to the oxygen absorbing device, one end is connected to the humidifier, and one end is connected to the complete oxygen absorbing tube to supply oral oxygen. The incidence of oropharyngeal dryness and the incidence of sore throat and satisfaction with nursing were compared between the two groups. Results The incidence of oropharyngeal dryness was 40.68% in the observation group and 89.83% in the control group. The incidence of oropharyngeal dryness in the observation group was significantly lower than that in the control group (P<0.05). The incidence of sore throat was 8.47% in the observation group and 62.71% in the control group. The sore throat in the observation group was significantly lower than that in the control group (P<0.05). The nursing satisfaction of the observation group was 91.52%, the nursing satisfaction of the control group was 76.27%, and the nursing satisfaction of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion The improved method can reduce the dry sensation of mouth and pharynx caused by mouth respiration during nasal tamponade, improve the comfort of pharynx, improve the satisfaction of pharyngeal care, and promote the patients' appetite.