Abstract: Objective Deep venous thrombosis of lower extremity occurs in patients with lower extremity fractures. Although conventional nursing can reduce the incidence of deep venous thrombosis of lower extremities, the nursing method is single and the prognosis is poor. This study focused on the nursing effect of perioperative predictive nursing in the prevention of deep venous thrombosis of lower extremities. Methods A total of 102 patients with lower extremity fractures who were treated from October, 2015 to October, 2017 were enrolled and randomly divided into control group (n=48) and observation group (n=54). The control group received routine nursing, and the observation group used perioperative predictive nursing intervention. After 15 days of nursing, the patient's nursing effect was evaluated. The incidence of deep venous thrombosis of the lower extremities was recorded in the two groups. The serum was separated and the two groups were measured by turbidimetry. Pre- and post-treatment 15 d D-dimer levels in the two groups were compared; color Doppler was used to detect venous blood flow velocity in lower limbs, and the incidence of deep venous thrombosis, coagulation function, and blood flow velocity were compared between the two groups. Results The incidence of deep venous thrombosis of the lower extremity was 1.85% in the observation group after perioperative care,which was lower than 18.75% in the control group (P<0.05). There was no significant difference in the D-dimer levels between the two groups before surgery(P>0.05); the level of D-dimer in the observation group was lower than that in the control group (P<0.05). There was no significant difference in blood flow velocity before treatment (P>0.05). The blood flow velocity level at 15 d was lower than that of the control group (P<0.05). Conclusion Perioperative predictive nursing can help reduce the incidence of deep venous thrombosis of lower extremities, improve blood coagulation and blood flow velocity, and is worthy of popularization and application.