Abstract: Objective By observing the VIS score and related inflammatory mediators in children with septic shock (SS), the prognostic value and nursing highlights of septic shock in children were discussed, in order to provide reference for clinical diagnosis and treatment. Methods Children with SS decompensated children who were admitted to PICU from January, 2012 to December, 2017 in our hospital were divided into observation group (survival) and control group (death) according to the final outcome of the disease, with 68 patients in the observation group and 42 patients in the control group. The VIS, BL levels, and procalcitonin (PCT) levels in the two groups were compared to determine the prognostic value of the disease and the nursing highlights. The correlation between VIS, BL, and PCT in the observation group was also analyzed. Results In the observation group, the first 24-hour VIS (29.2±4.2 vs. 11.4±3.3, t=23.36, P<0.01), BL level[(4.7±1.6) mmol/L vs. (5.9±2.1) mmol/L, t=3.385, P<0.01] and PCT levels[(7.8±1.5) ng/ml vs. (5.6±2.1) ng/ml, t=5.916, P<0.01] were significantly higher than those of the control group (all P<0.05). There was a statistically significant positive correlation between VIS and BL (r=0.493, P<0.001) and PCT (r=0.574, P<0.001) in the observation group. ROC curve analysis showed that with 20.3 as the cutoff value, VIS had a sensitivity of 85.71% and a specificity of 72.06% for predicting poor prognosis of SS, and the area under the curve was 0.804, which was better than BL and PCT. Conclusion VIS has a certain predictive value for the prognosis of children with SS, and nursing work also plays an important role in the process of diagnosis and treatment.