Abstract: Objective To study the effect of oral multivitamin beverage 2 hours before the anesthesia induction on gastric emptying and postoperative complications in children undergoing ophthalmic day surgery. Methods Total 120 children undergoing the day operation were selected and divided into the liquid fasting group, the glucose group and the multivitamin group (n=40) according to random number table. All patients in the three groups fasted 12 hours before the surgery. The patients in the liquid fasting group did not drink 6 before the anesthesia, The patients in the glucose group was given 10% glucose solution 2 hours before anesthesia, and the patients in the multivitamin group took take orally multivitamin beverage 2 hours before the anesthesia, the volume of liquid was 5 m L/kg bodyweight. The amount of gastric remnants was measured by B ultrasound before taking orally liquid (2 h before operation). Mask acceptability score was carried out immediately before the anesthesia. Ramsay sedation score and CHEOPS pain score were performed between the anesthesia and operation. The levels of blood glucose and insulin were tested before the anesthesia, immediately after the operation and 3 h after the operation. The complications was recorded. Results There were no statistical difference in the sedation score among the three groups (P > 0.05). The mask acceptability score of the multivitamin group was significantly higher than those of the other two groups (all P < 0.05). The CHEOPS pain score of the multivitamin group was significantly lower than those of the other two groups (all P < 0.05). There were no statistical difference in the amount of gastric remnants among the three groups (P > 0.05). In the multivitamin group, the time of restoration of anal exhaust was shorter, and the incidence of nausea and vomiting was lower, as compared with the other two groups. Blood glucose and insulin levels in the glucose group and multivitamin group was significantly higher than that in the liquid fasting group, however, these levels immediately after the operation in the liquid fasting group exceeded the glucose group and multivitamin group, the difference was statistical significant (all P < 0.05). There was no statistically difference in the levels of blood glucose and insulin levels 3 h after the operation and the incidence of complications among the three groups (all P > 0.05). Conclusion For the children undergoing surgery under general anesthesia, oral multivitamin 200 m L at 2 h before anesthesia induction can effectively alleviate the preoperative thirst, anxiety and relieve postoperative nausea, vomiting and other complications, without increasing the risk of reflux and aspiration.