Abstract: Objective To investigate the effect of Lucentis assisted vitrectomy on ocular function in patients with proliferative diabetic retinopathy (PDR). Methods A total of 200 patients (271 eyes) with PDR in our hospital from January 2016 to June 2018 were randomly divided into control group (100 cases, 126 eyes) and observation group (100 cases, 145 eyes). The control group was given vitrectomy, and the observation group was added Lucentis one week prior to vitrectomy. The surgical conditions, visual acuity, intraocular pressure, retinal thickness, and complications were compared between the two groups. The data were analyzed by statistical software to investigate the effect of Lucentis assisted vitrectomy on ocular function in patients with proliferative diabetic retinopathy (PDR). Results The operation time (71.8 ±11.4) min, the electrocoagulation hemostasis number (1.14 ±0.53) time, and the retinal tear rate (5.51%) of the observation group were significantly lower than those of the control group[(82.7 ±10.8) min, (1.78 ±0.52) times, 14.29%]. After treatment, the intraocular pressure and visual acuity of the two groups were significantly improved (P <0.05), and the observation group was superior to the control group (P < 0.05). The postoperative complications incidence of observation group was significantly lower than that of the control group (P < 0.05). The patient's complications were recovered after symptomatic treatment. Conclusion Lucentis assisted vitrectomy can effectively reduce the operation time, electrocoagulation number and retinal tear rate in patients with proliferative diabetic retinopathy, effectively improve intraocular pressure and visual acuity, and reduce postoperative complications.