Abstract: Objective Via health education intervention in patients with cardiovascular and cerebrovascular disease, we aim to analyze and evaluate the effect of health education for prevention of cardiovascular disease. Methods We selected 120 patients with disease of heart head blood-vessel as the research object from February 2014 to March 2015 within the area under the administration, and randomly divided them into control group and experimental group, with each 60 cases in each group. The control group was given general treatment method combined with basic health education, on the basis of which the experimental group was provided with health knowledge education, psychological counseling, and exercise therapy, together with guidelines for healthy diet, medications, family health education and treatment of complications, which constituted a comprehensive health education intervention. Real-time observation of two groups of patients was made in the process of treatment. Results With comprehensive health education and intervention on the patients, as well as knowledge test, we obtained the corresponding results. The health knowledge rate of experimental group was 96.7%, and the incidence of complications was 3.3%. For the control group, related knowledge rate was 71.7%, and the incidence of complications was 21.7%. There was significant difference (P < 0.05). Conclusion Via education intervention measures such as knowledge training, psychological intervention, diet guidance, medication guide, sports quality, family health education and so on, the patients greatly improved their knowledge in cardiovascular and cerebrovascular diseases, changed the wrong life habits, and developed a healthy way of living. Especially by comparison, the two groups fully illustrates that the health education for prevention of cardiovascular disease has significant effect, which is worth promoting in the daily life and intervention.