Abstract: Objective To explore the effect of teacher standardized patient teaching method on cultivating nursing students' professional skills and professional accomplishment in the teaching of Basic Nursing Science in secondary vocational schools. Methods Classes 1 and 2 of nursing sophomores in 21 secondary vocational schools were selected in a cluster. And 54 students in Class 1 were selected as the teaching group of standardized patients. Teachers standardized patients were added to the teaching group and case introduction, situational performance, evaluation feedback, consolidation summary and practice were carried out by means of simulation and multimedia. And 46 students in Class 2 were in the traditional teaching group. They are taught in theory-teacher 's Teaching-group practice mode. After the end of teaching, comprehensive examination and teaching satisfaction survey were conducted. The results were compared with t test and P < 0.05 was statistically significant. Satisfaction survey was conducted by two groups of students to evaluate the two teaching methods from five aspects:stimulating learning interest, improving critical thinking ability, improving the ability to solve nursing problems, improving language communication ability, and strengthening the concept of love and injury. Satisfaction was the percentage of students in the total number of students. Qualitative data were described by rate.Rank sum test was used to compare the differences (α=0.05). Results The total score of standardized patient teaching group was 85.72 ±4.62, which was significantly different from that of traditional group. Teachers'standardized patient teaching method is helpful to stimulate learning interest, improve critical thinking ability and ability to solve nursing problems, improve language communication ability and strengthen the concept of love and injury. Conclusion Teachers'standardized patient teaching method has achieved good results in improving students' professional knowledge, skills and professional quality. We should make proper use of teachers'standardized patients and explore the complementarity between teachers'standardized patients and other teaching methods in order to achieve better teaching results.