老年急性期脑梗死患者中FIB和HbA1c的水平变化及其与认知功能的相关性研究

俞梁; 顾大东; 杨越; 赵轲; 傅江; 傅锋

doi:10.16766/j.cnki.issn.1674-4152.000622

老年急性期脑梗死患者中FIB和HbA1c的水平变化及其与认知功能的相关性研究

doi: 10.16766/j.cnki.issn.1674-4152.000622

诸暨市人民医院神经内科一病区, 浙江诸暨 311800

基金项目:

浙江省医药卫生科技项目(2017ZYCA95)

详细信息

通讯作者:
顾大东,E-mail:zjsrmyyyl@163.com

中图分类号: R743.3
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出版历程
- 收稿日期: 2018-08-24
- 网络出版日期: 2022-08-04

The level change of FIB, HbA1c in acute cerebral infarction aged patients with different cognitive functions and their correlation with cognitive function

Department of Neurology, Zhuji People's Hospital of Zhefiang Province, Zhuji, Zhejiang 311800, China

摘要

摘要: 目的探讨纤维蛋白原(FIB)和糖化血红蛋白(Hb A1c)在老年急性期脑梗死患者中的水平变化及其与认知功能的相关性。方法选取2017年3月—2017年6月在诸暨市人民医院就诊的急性期脑梗死患者237例,根据蒙特利尔认知评估量表(MoCA)评分分为认知正常组114例,认知功能障碍组123例。比较2组的FIB、Hb A1c水平、认知情况,并且分析FIB和Hb A1c与认知情况的关系。结果认知功能障碍组FIB、Hb A1c水平明显高于正常组(均P<0.05);正常组的命名、语言、注意与计算力、抽象思维、视空间与执行能力、延迟回忆、定向力得分分别为(2.75±0.21)分、(2.61±0.52)分、(5.63±0.29)分、(1.68±0.31)分、(4.17±0.76)分、(4.52±0.36)分、(5.28±0.54)分,认知功能障碍组的命名、语言、注意与计算力、抽象思维、视空间与执行能力、延迟回忆、定向力得分分别为(2.26±0.31)分、(1.57±0.48)分、(3.04±0.38)分、(1.19±0.36)分、(3.28±0.37)分、(2.38±0.31)分、(5.03±0.46)分,认知功能障碍组的命名、语言、注意与计算力、抽象思维、视空间与执行能力、延迟回忆、定向力认知情况明显低于正常组(均P<0.05);FIB和Hb A1c分别与命名、语言、注意与计算力、视空间与执行能力、延迟回忆认知功能及MoCA总分均呈负相关(均P<0.05),但与抽象思维、定向力无相关性(均P>0.05)。结论 FIB、Hb A1c水平可反应老年急性期脑梗死患者的认知功能情况,可作为评判老年急性期脑梗死病程进展的依据。
- 糖化血红蛋白 /
- 纤维蛋白原 /
- 脑梗死 /
- 认知功能
Abstract: Objective To explore the level change of fibrinogen (FIB), glycosylated hemoglobin (Hb A1c) in acute cerebral infarction aged patients with different cognitive functions and their correlation with cognitive function. Methods A total of 237 acute cerebral infarction aged patients in our hospital were selected from March 2017 to June 2017. There were 114 cases in normal cognition group and 123 cases in cognitive dysfunction group according to the Montreal cognitive assessment scale (MoCA) score. The level of FIB and Hb A1c and the cognitive situation were compared between the two groups, and the relationship between FIB, Hb A1c and cognition were analyzed. Results The level of FIB and Hb A1c in the cognitive impairment group was significantly higher than those in the normal group (P < 0.05). The naming, language, attention and calculation, abstract thinking, visual-spatial and executive ability, delayed recall, and directional score in normal group was (2.75 ±0.21) points, (2.61 ±0.52) points, (5.63 ±0.29) points, (1.68 ±0.31) points, (4.17 ±0.76) points, (4.52 ±0.36) points, (5.28 ±0.54) points, respectively, the naming, language, attention and calculation, abstract thinking, visual-spatial and executive ability, delayed recall, and directional score in cognitive dysfunction group was (2.26 ±0.31) points, (1.57 ±0.48) points, (3.04 ±0.38) points, (1.19 ±0.36) points, (3.28 ±0.37) points, (2.38 ±0.31) points, (5.03 ±0.46) points, respectively, the naming, language, attention and calculation force, abstract thinking, visual space and executive ability, delayed recall and directional cognition of the cognitive dysfunction group were significantly lower than the normal group (all P < 0.05). FIB and Hb A1c were negatively correlated with naming, language, attention and computational power, visual space and executive ability, delayed recall, and total score of MoCA (all P < 0.05), but there is no correlation with abstract thinking and orientation (all P >0.05). Conclusion The level of FIB and Hb A1c can reflect the cognitive function of acute cerebral infarction aged patients, and they can be used as a basis for evaluating the progression of senile acute cerebral infarction.
- Glycosylated hemoglobin /
- Fibrinogen /
- Cerebral infarction /
- Cognitive function