Abstract: Objective To explore the application of multidisciplinary collaborative nursing model in Alzheimer's disease. Methods A total of 100 patients with Alzheimer's disease received in our hospital from January 2017 to January 2018 were randomly divided into routine group and multidisciplinary group with 50 cases in each group. The routine group received routine nursing care, and the multidisciplinary group received multidisciplinary cooperative nursing treatment. The patients were given mini-mental state examination before and after receiving nursing care. The scores of MMSE and ADAS-cog were compared between the two groups, and the quality of life and nursing satisfaction were evaluated. Results After nursing, the MMSE score of multidisciplinary group was higher than that of routine group, with statistical difference (P < 0.05); after nursing, the ADAS-cog score of multidisciplinary group was lower than that of routine group, with statistical difference (P <0.05). After nursing, the scores of quality of life in multidisciplinary group were higher than those in routine group, with statistical difference (P < 0.05). After nursing, the total recovery rate of multidisciplinary group was 86.00%, which was significantly higher than that of conventional group (64.00%, P < 0.05). The total satisfaction rate of multidisciplinary group was 94.00%, which was significantly higher than that of routine group (78.00%, P < 0.05). Conclusion Multidisciplinary collaborative nursing therapy can effectively improve the clinical symptoms of patients with Alzheimer's disease, improve the quality of life of patients, and help patients with early rehabilitation.