Abstract: Objective To investigate the effect of comprehensive nursing intervention on psychological state and immunity of patients with cervical cancer and depression. Methods A total of 152 patients with cervical cancer and depression from December 2016 to December 2017 were randomly divided into two groups, with 76 cases in each group. The control group received routine nursing and the observation group received comprehensive nursing intervention. Before and after nursing, the depression status (SDS score, SAS score), life quality (GQOLI-74 score), immune status (CD3⁺, CD4⁺, CD8⁺, CD4⁺/CD8⁺) and serum inflammatory factors (TNF-α, IL-6 and IL-10) of two groups were compared. Results After nursing, the SDS and SAS scores of two groups significantly reduced (all P < 0.05), and observation group was significantly lower than control group (all P < 0.05). After nursing, the levels of CD3⁺, CD4⁺and CD4⁺/CD8⁺ of two groups were significantly increased (all P < 0.05), and observation group was significantly higher than control group (all P < 0.05). The CD8⁺ levels of two groups were significantly reduced (P < 0.05), and observation group was significantly lower than control group (P < 0.05). After nursing, the body function dimension, social function dimension, psychological function dimension and material life dimension score of the two groups significantly increased (all P <0.05), and observation group was significantly higher than control group (all P < 0.05). The TNF-α, IL-6 and IL-10 levels of two groups significantly reduced (all P < 0.05), and observation group was significantly lower than control group (all P < 0.05). Conclusion Comprehensive nursing intervention could improve the depression status immunity, life quality and body's inflammation levels of patients with cervical cancer.