Abstract: Objective Enuresis is a common and frequently occurring disease, and the treatment effect of western medicine is not so satisfied. The purpose of this study is to compare the curative effect of Suoquan and Xingpi Yanger granule in children with different clinical syndromes, so as to guide clinicians to select appropriate drugs according to clinical syndromes. Methods According to the clinical symptoms, auxiliary examination results and therapeutic standards of TCM syndrome for pediatric enuresis, 21 enuresis children without basic diseases, such as diabetes and epilepsy, were divided into deficiency of kidney-qi group (n=10), and deficiency of spleen and lung-qi group (n=11), who were treated in the Department of Rheumatism of Shanghai Children's Medical Center from June 1 to November 31 in 2017. The deficiency of kidney-qi group, with admission syndrome of growing development and urinary symptoms, was treated with Suoquan capsule for 3 months; the deficiency of spleen and lung-qi group, with admission syndrome of gastrointestinal symptoms, body weight, tooth marks and tongue coating, was treated with Xingpi Yanger granule for 3 months. And the therapeutic effects, adverse drug reactions and recurrence rate were observed. Results In the deficiency of kidney-qi group, 4 cases were CR, 3 cases were PR, and 3 cases were PD, with a total effective rate of 70.00% (7/10). In the deficiency of spleen and lung-qi group, 4 cases were CR, 4 cases were PR, and 3 cases were PD, with a total effective rate of 72.72% (8/11). There was no significant difference in the curative effect between the two groups (P>0.05). Three months follow-up did not observed the obvious adverse reaction and recurrence case. Conclusion The rational use of Suoquan capsule or Xingpi Yanger granule in the treatment of infantile enuresis according to the clinical signs (enuresis, urinary and gastrointestinal symptoms), body weight and growth status will achieve the desired result. The method, with good clinical practicality, is simple and convenient.