Abstract: Objective To investigate the effect of Shenlingbaizhu powder on senile sepsis patients with intestinal dysfunction and its influence on hemorheology and immune function. Methods A total of 66 senile sepsis patients with intestinal dysfunction in Zhejiang Province People's Hospital from January 2016 to June 2017 were enrolled and divided into observation group (33 cases) and control group (33 cases) according to the random number table method. The control group was treated with western medicine, while the observation group was supplemented with Shenlingbaizhu powder on the basis of the control group. The length of hospital stay and intensive care unit (ICU) stay, 28 d mortality, clinical efficacy, hemorheology and immune function of the two groups were compared. Results The length of hospital stay, ICU stay and 28 d mortality of the patients in the observation group were significantly lower than those in the control group (all P<0.05). After treatment, the acute physiology and chronic health evaluation (APACHE Ⅱ) score, intestinal dysfunction score and the levels of serum diamine oxidase (DAO) decreased significantly in both groups (all P<0.05), and these indexes in the observation group were significantly lower than those in the control group (all P<0.05). After the treatment, the levels of high whole blood high-shear viscosity, whole blood lower-shear viscosity and plasma viscosity in two groups decreased significantly (all P<0.05), and those in the observation group was significantly lower than those in the control group (all P<0.05). After treatment, the levels of immunoglobulin-A (IgA), IgG and IgM in the two groups increased significantly (all P<0.05), and the level of IgA and IgG in the observation group was significantly higher than that in control group (all P<0.05), however, there was no significant difference in the level of IgM between the two groups (all P>0.05). Conclusion Shenlingbaizhu powder is effective in treating senile sepsis patient with intestinal dysfunction through improving intestinal dysfunction, hemorheology and immune function of the patients.