Abstract: Objective To investigate the levels of adipokines in patients with rheumatoid arthritis (RA) and to explore their association with DAS28. Methods One hundred and twenty-six patients with RA admitted to Jinhua central hospital from March 2017 to August 2017 were selected as observation group. One hundred people who received physical examination in our hospital during the same period were selected as control group. The levels of visfatin, adiponectin and resistin in two groups were compared. Then, according to the patient's disease activity, 126 patients with RA were divided into 47 patients with high activity group and into 79 patients with moderate-low activity group, the serum lipid, adiponectin and resistin levels were measured by enzyme linked immunosorbent assay(ELISA) the levels of visfatin, adiponectin and resistin were compared between the two groups. Finally, pearson correlation analysis was used to analyze the correlation between the levels of lipoprotein, adiponectin, resistin in patients and DAS28. Results Visfatin was (6.68±1.25) ng/L, adiponectin was (11.36±3.29) μg/mL and resistin is (13.78±4.21) ng/mL in the observation group, visfatin was (4.13±1.16) ng/L, adiponectin was (6.57±1.38) μg/mL and resistin was (6.85±2.34) ng/mL in the observation group, the levels of visfatin, adiponectin and resistin in the control group were significantly higher than those in the control group(P<0.05). Visfatin was (4.81±1.95) ng/L, adiponectin was (22.64±8.96) μg/mL and resistin was (15.72±7.97) ng/mL in the highly active group, visfatin was (4.05±1.66) ng/L, adiponectin was (19.35±9.62) μg/mL and resistin was (13.28±5.96) ng/mL in the moderate-low activity group, the levels of visfatin in the highly active group was significantly higher than that in the moderate-low activity group(P<0.05), there was no significant difference in adiponectin and resistin levels between the two groups(P>0.05). Pearson correlation analysis showed that the levels of serum visfatin, adiponectin, and resistin were positive correlated with the DAS28 score (P<0.05). Conclusion The levels of adipokines in RA patients are high, especially in patients with higher disease activity and positively correlated with DAS28 scores, suggesting that adipokines may be involved in the inflammatory immune response of RA and can be used as a measure of disease activity in patients.