Abstract: Objective To evaluate the quality-of-life, anxiety and depression in patients with facial dermatitis, and to analyze the possible impact factors. Methods Totally 85 patients with facial dermatitis were recruited. They were assessed with erythra severity score, Visual Analogue Sale (VAS), Dermatology Life Quality Index (DLQI) and Hospital Anxiety and Depression Scale (HADS), while outcomes and related factors were analyzed by SPSS 23.0. Results The patients with facial dermatitis scored higher in HADS than the healthy controls (P<0.05), the mean scores of "anxiety" and "depression" were HAD-A 5.14±3.12 and HAD-D 3.76±3.06 respectively, 21.3% were anxious, 12.5% were depressed, and 8.8% were both anxious and depressed. Quality of life was impaired obviously (DLQI scored 8.89±6.03). The age, gender, and course of disease have no correlation with quality of life, anxiety or depression level. Erythra severity scores were negatively correlated with Quality of life (r=0.261, P<0.05), meanwhile they showed no correlation with anxiety and depression level (P>0.05). The degree of itch (VAS) was positively correlated with anxiety level (r=0.403, P<0.01), negatively correlated with Quality of life (r=0.513, P<0.01), and it showed no correlation with depression level. Multivariable regression showed that pruritus was an independent impact factor of anxiety and quality-of-life in patients with facial dermatitis. Conclusion The patients with facial dermatitis had higher levels of anxiety and depression compared with healthy controls, and lower quality of life. Quality of life was negatively affected with both subjective and objective symptoms severity. Anxiety level was only negatively affected with Subjective severity (degree of itch). The more severe itching, the worse the quality of life, and the higher the anxiety level. Not only disease but also patients' psychological needs should be paid attention in clinical work, and multidisciplinary treatment should be tried.