Abstract: Objective To explore the clinical value of evidence-based nursing intervention in the treatment of patients with skin ulcers with Ruyi golden yellow powder. Methods A total of 100 patients with skin ulcers who were treated in our hospital from August 2016 to August 2017 were selected, and were divided into routine nursing group and evidence-based nursing group with 50 cases in each group according to the numerical randomization method. Patients with skin ulcers were selected for the treatment with ruyi golden powder external application, and the conventional nursing group received basic nursing and the evidence-based nursing group received evidence-based nursing intervention. The self-rating Anxiety Scale (SAS) and self-rating Depression Scale (SDS) of the two groups were statistically analyzed, as well as the scores of quality of life and quality of care. The satisfaction rates of patients and family members in both groups were calculated. Results After nursing, the SAS and SDS scores of patients in the conventional nursing group and the evidence-based nursing group were significantly decreased, and the SAS and SDS scores of patients in the evidence-based nursing group were lower than those in the conventional nursing group, showing a statistical difference (all P<0.05). After nursing, the scores of somatic function, emotional function and social function of patients in the two groups all increased to some extent, and the scores of somatic function, emotional function and social function of patients in the evidence-based nursing group were higher than those in the conventional nursing group, showing statistical differences (all P<0.05). Patients in the evidence-based nursing group with skin sores were hospitalized for a shorter time and had a higher quality of care score, which was statistically different from the conventional nursing group (all P<0.05). The total satisfaction of family members of the evidence-based nursing group was as high as 96.00%, significantly higher than that of the routine nursing group (84.00%), showing a statistical difference (P<0.05). Conclusion Evidence-based nursing can significantly improve patients' mental state, promote patients' physical recovery and make patients and their families more satisfied.