急性期带状疱疹患者病情、病毒载量、S100β及NSE水平与PHN的相关性研究

蔡薇; 丁娟; 金重赢

doi:10.16766/j.cnki.issn.1674-4152.000689

急性期带状疱疹患者病情、病毒载量、S100β及NSE水平与PHN的相关性研究

doi: 10.16766/j.cnki.issn.1674-4152.000689

蔡薇^1, ,,
丁娟¹,
金重赢²

1. 绍兴市人民医院皮肤科, 浙江绍兴 312000;
2. 浙江大学医学院附属邵逸夫医院, 浙江杭州 310000

基金项目:

浙江省医药卫生科技计划项目(2016KYB146)

详细信息

通讯作者:
蔡薇,E-mail:canny6330@sina.com

中图分类号: R752.12;R373.11
计量
- 文章访问数: 114
- HTML全文浏览量: 10
- PDF下载量: 0
- 被引次数: 0
出版历程
- 收稿日期: 2018-08-23

Correlation between PHN and patient' s condition, VZV load, S100β, NSE level in patients with acute stage herpes zoster

Department of Dermatology, Shaoxing People's Hospital of Zhejiang Province, Shaoxing, Zhejiang 312000, China

摘要

摘要: 目的探讨急性期带状疱疹(HZ)患者病情评分、水痘-带状疱疹病毒(VZV)DNA载量、血浆S100β蛋白、神经元特异性烯醇化酶(NSE)的水平变化情况,并分析其与带状疱疹后遗神经痛(PHN)的关系。方法选择2016年11月-2017年5月入住绍兴市人民医院的急性期HZ患者56例作为观察组,于治疗前后对HZ患者的病情进行评分,同时检测VZV DNA载量、血浆S100β蛋白和NSE水平,并选择同期体检的健康志愿者50例作为对照组。于治疗后1个月随访HZ患者发生PHN的情况,并采用Spearman相关性分析分析PHN与HZ患者病情评分、VZV DNA载量、血浆S100蛋白和NSE的关系。结果 HZ患者治疗后病情评分明显低于治疗前(P<0.05);对照组血液中均未测出VZV DNA,观察组HZ患者疱液均检测出VZV DNA;治疗前HZ患者外周血VZV DNA呈现阳性者21例(37.5%),治疗后HZ患者外周血VZV DNA呈现阳性者7例(12.5%),HZ患者外周血治疗前后VZV DNA载量均明显低于HZ患者疱液的VZV DNA载量(均P<0.05),且治疗后HZ患者外周血VZV DNA载量明显低于治疗前(P<0.05);观察组治疗前后S100β、NSE水平均明显高于对照组(均P<0.05),治疗后观察组S100β、NSE水平均明显低于治疗前(均P<0.05);治疗前PHN与病情评分、疱液VZV、NSE呈正相关(r=0.347、0.562、0.281,均P<0.05),与外周血VZV、S100β无关;治疗后,PHN与病情评分、外周血VZV、S100β和NSE均呈正相关(r=0.606、0.594、0.606、0.379,均P<0.05)。结论 HZ患者病情评分、VZV载量、S100β、NSE水平的变化情况对PHN的发生具有一定的预测价值。
- 带状疱疹 /
- 水痘-带状疱疹病毒 /
- 神经元特异性烯醇化酶 /
- 带状疱疹后遗神经痛
Abstract: Objective To investigate the changes of the patient's condition, varicella zoster virus (VZV) load, plasma S100β, neuron specific enolase (NSE) level in acute stage herpes zoster (HZ), and analyze their relationship with postherpetic neuralgia (PHN). Methods Fifty-six patients were selected from November. 2016 to May 2017 in our hospital with acute stage of HZ as observation group, before and after treatment to evaluate HZ patients condition, detect VZV DNA loads at the same time, plasma S100βand NSE level, and in the same period, 50 healthy volunteers were selected as control group. After 1 month follow-up of PHN in patients with HZ, the relationship between PHN and HZ patient's disease, VZV DNA load, plasma S100β and NSE were analyzed by Spearman. Results After treatment, the score of HZ patients was significantly lower than before treatment (P<0.05); No VZV DNA was detected in the blood of the control group, VZV DNA was detected in blister fluid of HZ patients in observation group, before treatment, there were 21 cases (37.5%) of VZV DNA positive in patients with HZ, after treatment, there were 7 cases (12.5%) of VZV DNA positive in peripheral blood of HZ patients, before and after treatment, the VZV DNA load in peripheral blood of HZ patients was significantly lower than that of the VZV DNA load in blister fluid of HZ patients (all P<0.05), and the VZV DNA load in peripheral blood of HZ patients after treatment was significantly lower than before treatment (P<0.05); Before and after treatment, the S100β and NSE levels of the observation group were significantly higher than the control group (all P<0.05), and after treatment, the S100β and NSE levels of the observation group were significantly lower than before treatment (all P<0.05); Before treatment, PHN was positive correlated with the disease, VZV and NSE (r=0.347, 0.562, 0.281; all P<0.05), and was unrelated to peripheral blood VZV and S100β, after treatment, PHN was positive correlated with the disease, peripheral blood VZV, S100β and NSE (r=0.606, 0.594, 0.606, 0.379; all P<0.05). Conclusion The changes of HZ patient's condition score, VZV load, S100β and NSE level have certain predictive value for PHN.
- Herpes zoster /
- Varicella zoster virus /
- Neuron specific enolase /
- Postherpetic neuralgia