Prognostic role of inflammatory biomarkers in gliomas
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摘要: 目的 探讨血液中的炎症指标对于神经胶质瘤患者预后的预测价值,包括C反应蛋白(C-reactive protein,CRP)中性粒细胞与淋巴细胞比(neutrophil-lymphocyte ratio,NLR)和红细胞沉降率(the erythrocyte sedimentation rate,ESR)。 方法 回顾性分析2010年1月-2016年1月浙江省瑞安市人民医院第三附属医院收治的178例神经胶质瘤患者的临床病理资料,采用Kaplan-Meier法绘制生存曲线,生存的曲线比较采用Log-rank检验,单因素和多因素分析采用COX模型,分析神经胶质瘤患者预后的相关因素。 结果 NLR、CRP与神经胶质瘤患者的肿瘤大小、分化程度、血管神经侵犯相关(均P<0.05),ESR与神经胶质瘤患者的肿瘤大小相关(P<0.05);通过生存曲线分析可以得出:低NLR组、低CRP、低ESR组神经胶质瘤患者的总生存时间较高NLR组、高CRP、高ESR组长(P<0.05);分化程度(P<0.05)、CRP(P<0.05)和NLR(P<0.05)为影响神经胶质瘤患者预后的独立因素。 结论 NLR和CRP对于神经胶质瘤患者有较好的预测价值。Abstract: Objective To assess the prognostic significance of inflammatory biomarkers, including the C-reactive protein (CRP), neutrophil lymphocyte ratio (NLR) and the erythrocyte sedimentation rate (ESR), in gliomas. Methods Clinico-pathological data of 178 patients with gliomas in Zhejiang Rui'an Renmin Hospital between January 2010 and January 2016 was analyzed retrospectively in this study. Survival curves were described by Kaplan-Meier method and compared by Log-rank test. The univariate and multivariate analyses were performed with the Cox proportional hazard model to identify the prognostic factors. Results The NLR and CRP were associated with the tumor size, differentiation degree and lymphovascular invasion (all P<0.05). PLR was positively correlated with the tumor size (P<0.05). The Kaplan-Meier curves showed that the patients with gliomas had a longer time in the low NLR group, low CRP group and low ESR group than in the high NLR group, high CRP group and high ESR group respectively, showing a significant difference (all P<0.05). The multivariate analyses showed that the differentiation degree, CRP and NLR were independent factors for predicting overall survival of gliomas patients. Conclusion The CRP and NLR have prognostic value for predicting overall survival in gliomas patients.
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