Abstract: Objective To observe the efficacy and safety of laparoscopy, duodenoscopy and choledochoscope in the treatment of extrahepatic bile duct stones, in order to provide data support for the formulation of treatment plan. Methods Total 82 patients with extrahepatic bile duct stones diagnosed in our department from August 2017 to August 2018 were selected. They were included in the control group (41 cases) and the observation group (41 cases) according to the random number table method. The control group was treated with routine laparoscopic combined with choledochoscope. The observation group was treated with laparoscopic and duodenoscope combined with choledochoscope. The success rate, stone removal rate and prognosis of the two groups were compared. Bed efficacy, clinical indicators (operation time, bleeding volume, anal exhaust time, recovery time of gastrointestinal function, out-of-bed activity time, hospital stay), complications (incision infection, common bile duct injury, bile leakage, gastrointestinal perforation) and quality of life (SF-36 score). Results The success rate (97.6%) of the observation group was higher than that in the control group (80.5%), the total efficiency of the Observation Group (92.7%) was higher than that in the control group (75.6%), and the operation time of the observation group was longer than that in the control group. The incidence of complications in the Observation Group (4.9%) was lower than that in the control group (19.5%), the scores of SF-36 in the observation group were higher than those in the control group, and the differences were statistically significant in each group (all P<0.05). The stone clearance rate in the observation group (95.1%) was slightly higher than that in the control group (90.2%), with no significant difference (P>0.05). Conclusion The three-mirror combination therapy for extrahepatic bile duct stones is effective, with high success rate, rapid recovery, good prognosis and other advantages, which is worth promoting.