Abstract: Objective To investigate the clinical effect of Xiaoyao san (menstrual period) and Guishao Wuzi decoction (non-menstrual) combined with Shenqi glucose injection on the treatment of uterine artery resistance increased recurrent abortion. Methods A total of 80 patients with uterine artery resistance increased recurrent abortion from January 2016 to June 2017 in our hospital were divided into two groups according to the random number method, with 40 in each group. Before the pregnancy, the control group was given aspirin, and the observation group was given Xiaoyao san (menstrual period) plus Guishao Wuzi decoction (non-menstrual) combined with Shenqi glucose injection. Two groups were treated for 3 courses. After treatment, the TCM syndrome score, the bilateral uterine artery blood flow resistance index (RI) and the bilateral uterine artery systolic peak flow rate/end diastolic flow rate (S/D) ratio of two groups, as well as serum chorionic gonadotropin (β-HCG) and progesterone (P) at Pregnancy 30 days and 56 days in two groups were compared, and the pregnancy success rate after pregnancy was accounted. Results After treatment, the TCM syndrome scores of the two groups were significantly lower (P<0.05), and the observation group was significantly lower than the control group (P<0.05). After treatment, the sum of the left RI, right RI and S/D ratios was significantly lower (P<0.05), and the observation group was significantly lower than the control group (P<0.05). The β-HCG and P levels of observation group at pregnancy 30 days and 56 days were significantly higher than that of control group (P<0.05). After treatment, the success rate of the fetus in the observation group was 86.84%, which was significantly higher than that of the control group (67.56%), P<0.05. Conclusion Xiaoyao San (menstrual period) plus Guishao Wuzi Decoction (non-menstrual period) combined with Shenqi glucose injection could effectively treat uterine artery resistance increased recurrent abortion, significantly improve the clinical symptoms and reduce uterine artery blood flow resistance, and improve the success rate of patients with abortion.