Abstract: Objective To explore the feasibility, safety and some factors influencing the efficiency of magnetically controlled capsule endoscopy (MCE) in upper gastrointestinal tract disease screening. Methods Sixty patients with upper gastrointestinal symptoms undergoing MCE in our hospital between March 2017 and March 2018 were selected to record the main anatomical site within the stomach esophagus, gastric mucosa visibility, and time for capsule through gastrointestinal tract, detection of upper gastrointestinal disease, success rate of inspection and incidence of discomfort. Thirty of 60 cases underwent gastroscopy at 4 weeks before and after MCE to detect diseases. The operation safety, feasibility and tolerance of MCE, disease detection rate and the influence of age on esophagus through time were evaluated. Results In 60 patients, the completion rates of cardiac examination, gastric fundus examination, gastric body examination, gastric Angle examination, gastric sinus examination and pylorus examination were 85.00%, 88.33%, 100.00%, 95.00%, 98.33% and 100.00%, respectively. There was no statistically significant difference in the time of capsule through esophageal tract between the patients aged 60y and less than 60y. Among them, 43 cases of upper digestive tract lesions were found, with a positive diagnosis rate of 71.67% (43/60), and 30 patients underwent gastroscopy within 4 weeks before and after the examination, with a consistent rate of 90.0% (27/30). All 60 patients successfully finished MCE examination, and 1 patient suffered discomfort, and the capsule was discharged within 1 week. Conclusion Compared with gastroscopy, MCE has a high detection rate of upper digestive tract lesions, and the examination process is noninvasive and controllable, which can be used for the screening of upper digestive tract diseases.