Abstract: Objective To evaluate the effect of routine hypertension therapy based contract service on the long-term prescription in Shanghai. Methods Two hundreds subjects were selected according to the inclusive criteria from September 2016 to February 2018, and were randomly assigned to long prescription group and non-long prescription group. The subjects in long prescription group signed the chronic disease long-term description service, and received the drugs for 8 weeks every visiting time. While the subjects in non-long prescription group only received drugs for 4 weeks. The study lasted 6 months. All subjects were tested and evaluated both at the beginning and end of the term. Results In the long prescription group, there were no significant differences insystolic and diastolic blood pressure before and after treatment (all P>0.05); there were significant differences in medication compliance, service satisfaction, patient visits, the time of medical treatment and the cost of medical treatment within 6 months. The net change values between the two groups were not significant in both systolic and diastolic blood pressure (all P>0.05); there were significant difference in cognitive symptom management, symptom management self-efficacy, communication with doctors, health self-assessment, health concerns, the impact of disease on life, medication compliance, service satisfaction, medical visits, the time and cost of medical treatment within 6 months (all P<0.05). Conclusion Our results showed that the effects of routine hypertension therapy based contract service on the long-term prescription were promising in our community. The long prescription model can be borrowed to manage other chronic diseases community health service centers.