Abstract: Objective To explore the application effect of internet-based mindfulness decompression therapy psychological nursing in the nursing of patients with inflammatory arthritis. Methods From July 2017 to November 2018, 126 patients with inflammatory arthritis which met the inclusion and exclusion criteria were enrolled in the Department of Rheumatology and Joint Surgery, and 126 patients were randomly divided into two groups, namely experimental group (62 cases) and control group (64 cases) using the convenient sampling method. The mental health education was given to the control group, and the experimental group was given Internet-based mindfulness decompression therapy intervention. The depression level, anxiety level, mindfulness level, quality of life, cortisol concentration and personality traits of the two groups were compared before and after the intervention. Results Before the intervention, there was no statistically significant difference in scores on these indicators between the two groups. After the intervention, the scores of depression BDⅠ-Ⅱ, anxiety SAS, comprehensive quality of life, cortisol concentration, neuroticism, psychoticism and dissimulation in the experimental group were all lower than those in the control group, mindfulness score and introversion dimension score were higher than those in the control group, and the difference was statistically significant (all P<0.05). Conclusion Internet-based psychological care for mindfulness decompression therapy can alleviate the negative emotions of patients with inflammatory arthritis, improve the level of mindfulness and quality of life, adjust the function of the hypothalamic-pituitary-adrenal axis, improve personality traits, and promote clinically. Internet based mindfulness stress reduction psychological nursing therapy could provide data support and practical experience.