Abstract: Objective To study the clinical application of systematic rehabilitation nursing in neurogenic bladder of patients with traumatic spinal cord injury(TSCI). Methods Sixty patients with TSCI admitted to the Affiliated Hospital of Medical College of Ningbo University from June 2017 to March 2018 were divided into intervention group and control group according to the random group design, by admission period. The control group of 30 patients were given routine nursing. On the basis of routine nursing, the intervention group of 30 patients were given individualized bladder function training, intermittent catheterization demonstration, psychological intervention, diet care, follow-up supervision and other systematic rehabilitation care. The quality of life (QOL), bladder function, incidence of urinary tract infection and satisfaction rate of nursing were evaluated after 6 months of continuous intervention. Results There was no significant difference in urinary tract infection between the two groups, but the number of infections in the intervention group was lower than that in the control group. The time required for the intervention group to reach the equilibrium state of the bladder was significantly shorter than that of the control group (P<0.05), and the satisfaction rate of the nursing work in the intervention group was also significantly higher than that of the control group (P<0.05). There was no significant difference in defects and coercion between the two groups. The intervention group was significantly better than the control group in terms of anxiety and emotion (both P<0.05). Conclusion Systematic rehabilitation nursing intervention can significantly shorten the time required for NB patients to reach the equilibrium state of the bladder, reduce the incidence of urinary tract infections, help to reduce the anxiety of patients, improve the quality of life of patients and the satisfaction rate of nursing work, and effectively improve the healing effect of neurogenic bladder.