Abstract: Stroke has become an important disease that threatens our lives. It is well known that stroke is a preventable disease. Of course, there are more and more treatments for this disease. But stroke, particularly wake-up stroke seems to be limited in our current treatment, and we lack understanding of this type of stroke, and such clinical stroke, accounting for a large proportion. We only use anti platelet aggregation, stable plaques, and protection of the cranial nerve treatment. The development of clinical thrombolysis and intravascular therapy has provided a powerful solution for the treatment of stroke. However, due to insufficient knowledge of post-wake stroke, the treatment of post-wake stroke has been limited, so that we lack the active and effective means to alleviate or improve the symptoms and prognosis of patients. Combined with the existing imaging development, stroke thrombolysis and mechanical we collect the bolt may need to change the original views, as we understand further from the original time window of stroke transition to the window, it could also mean we can provide new insights through effective screening to stroke patients. We see the dawn, we see the challenges, and the future can have large samples, random, multicenter studies that provide more evidence for this type of stroke. The history of stroke is also the history of human progress. We constantly update knowledge, constantly breakthroughs; our ultimate aim is to bring benefit to our patients. Yet, the most important thing is to renew the idea, however, the patient should renew the idea, however our clinical workers also need to update the knowledge, and renew the idea. This requires us to constantly learn and constantly update our thinking. We used to focus on time, but with modern technology, especially imaging. The treatment of stroke is likely to transition from time window to tissue window, thanks to the development of imaging. The development of neuroimaging has provided a more powerful tool for stroke, and new keys have been opened for the treatment of post-resuscitation stroke, to study the relevant literature on stroke after awakening.