Abstract: Objective To analyze the effect of multidisciplinary collaborative process management on hospital transport of critical patients in emergency department. Methods Three hundred and eighty patients in emergency department from January 2017 to December 2017 were randomly divided into the control group and the observation group, 190 patients in each group. The observation group was managed in-hospital transport by using multidisciplinary process management. The process management included the establishment of in-hospital transport group for critical patients in emergency department, and multidisciplinary joint development of transport flow chart. The control group was transported by emergency routine procedure. The changes of nursing defect rate and satisfaction degree of family members were compared between the two groups. Results Multidisciplinary collaborative process management led to the transfer of critical patients from single operation to multi-disciplinary collaboration. Nursing deficiencies were compared between the two groups. This study showed that the incidence of accidental extubation was reduced from 4.2% to 1.9%; the incidence of missing items was decreased from 4.7% to 1.6%; the incidence of transfusion tube shedding or obstruction was reduced from 5.3% to 1.1%; MEWS score rate was from 4.7% to 1.1%. The incidence of adverse events in the two groups was significantly lower than that in the control group, the difference was statistically significant (P<0.001). The satisfaction degree of the observation group was significantly higher than that of the control group (P<0.001). Conclusion The application of multi-disciplinary cooperative process management embodies the advantages of two-way or multi-disciplinary cooperation, makes the hospital transfer process more streamlined and systematic, ensures the safety and efficiency of critical patients in the process of transport, promotes the improvement of transport quality and improves the satisfaction of patients' family members.