Abstract: Objective To investigate the effect of integrated nursing intervention on postoperative patients with thoracolumbar fractures. Methods A total of 110 patients with thoracolumbar fractures treated with pedicle screw internal fixation from May 2017 to October 2018 were selected as the study subjects. According to the random number table method, they were divided into observation group and control group, with 55 cases in each group. The control group was treated with conventional nursing method, and the observation group was treated with integrated nursing intervention on the basis of the control group. The effect of functional recovery (excellent rate of lumbar and dorsal muscle function recovery), pain degree score (VAS score), mental state score (SAS, SDS score) before and after nursing intervention, and complications during hospitalization were compared between the two groups. Results The excellent and good recovery rate of lumbar muscle function in the observation group was 92.7% (51/55), which was significantly higher than that in the control group (78.2%,43/55), P<0.05. Before nursing intervention, there was no significant difference in pain score and mental state score between the two groups(P>0.05); after nursing intervention, the VAS score of the observation group was significantly lower than that of the control group (P<0.05); after nursing intervention, the SAS score and SDS score of the observation group were lower than those of the control group (P<0.05); during the nursing intervention, the observation group was concurrent. The total incidence was 25.5%(14/55), which was lower than 45.5% (25/55) of the control group(P<0.05). Conclusion Holistic nursing intervention can significantly improve the postoperative functional recovery of patients with thoracolumbar fractures, reduce the pain of patients, alleviate the bad mood of patients and reduce the incidence of complications, which is worthy of clinical application.