Abstract: Objective To investigate the clinical value of D-dimer (D-D) and cystatin C (CysC) in predicting restenosis after cerebrovascular intervention. Methods Total 118 patients with ischemic cerebrovascular disease in our hospital from April 2015 to September 2017 were treated with endovascular stent implantation. Venous blood samples were collected on the day after admission and 3 days after surgery. Serum DD and CysC levels were measured, restenosis conditions of all patients within 1 year after operation were counted. They were divided into restenosis group and non-stenosis group. The predictive ability of postoperative restenosis with serum DD and CysC was analyzed. Results Of the 118 patients,there were 16 cases of restenosis within 1 year after operation, the restenosis rate was 13.56%. There were no significant differences in preoperative basic data and serum DD and CysC levels between the restenosis group and the non-stenosis group (all P>0.05). There was no significant change in serum DD and CysC levels in the non-stenosis group (all P>0.05), serum DD and CysC levels were significantly increased in the stenosis group (all P<0.05), serum DD and CysC levels were significantly higher than those in the non-stenosis group at 3 days after surgery (all P<0.05). Multivariate logistic regression analysis showed that high D-D and CysC levels were independent risk factors for postoperative restenosis (all P<0.05). The areas under the working characteristic curve (ROC) of predicting postoperative restenosis by serum DD, CysC and the combination of the two were 0.786, 0.825 and 0.907, respectively. The optimal cut-off value of serum DD and CysC were 356.22 μg/L, 1.41 mg/L, the sensitivity and specificity of predicting postoperative restenosis by the combination of DD and CysC were 87.50% and 93.14%, respectively. Conclusion High DD and CysC levels after cerebrovascular intervention are risk factors for restenosis. It has a high predictive effect on postoperative restenosis. Close monitoring of serum DD and CysC levels can help to assess the risk of restenosis and timely develop individualized prevention and treatment countermeasures.