Abstract: Objective To evaluate the clinical effect of Duhuo Jisheng decotion assisted treatment for rheumatoid arthritis(RA) on effect of serum matrix metalloproteinase-2(MMP-2), inflammatory cytokines and coagulation function. Methods A total of 86 consecutives as RA active stage from June 2017 to June 2018 were enrolled and divided randomly into control and observation groups, each of 43 cases. The control group received oral Tripterygium Glycosides 20 mg/d, tid; the observation group adopted Duhuo Jisheng decotion at the mean time, the course was one month. Then, the DAS28 score, serum MMP-2 level, inflammatory cytokines CRP and IL-6, coagulation function including D-dimer(D-D), fibrinogen(FBG), prothrombin time(PT)and partial thromboplastin time (APTT)and clinical effect were compared. Results The DAS28 score, levels of MMP-2, CRP and IL-6 in the two groups after treatment were lower than before, and they in observation group were significantly less than control group(all P＜0.05). The same to D-D, FBG, PT and APTT values, too(all P＜0.05). What's more, the clinical total efficacy rate in observation group was significantly higher(P＜0.05). There were no serious adverse reactions in both groups and the drug was not interrupted. Conclusion It can furtherly improve serum MMP-2, inflammatory cytokines and coagulation function in RA active stage with Duhuo Jisheng decotion assisted treatment in order to improve clinical effect.