Effect and prognosis of acupuncture on polycystic ovary syndrome
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摘要: 目的 分析针灸治疗多囊卵巢综合征对患者性激素、胰岛素(INS)、皮质醇(Cor)、17-羟孕酮(17-OHP)、硫酸脱氢表雄酮(DHEA-S)水平及妊娠率、排卵率、流产率的影响。 方法 选取宁波大学医学院附属医院于2016年8月—2017年9月收治的100例多囊卵巢综合征患者,按随机数字表法分为2组,各50例。对照组患者采用常规治疗,口服黄体酮片引起撤药性出血后5 d口服枸橼酸氯米芬片,1次/d。观察组患者在常规治疗基础上给予针灸治疗,取中极、子宫、肾俞、血海等为主穴,针刺得气后行平补平泻法,留针30 min,每10 min行针1次。采用电化学发光法检测性激素、INS、Cor、17-OHP、DHEA-S水平,记录妊娠率、排卵率、流产率情况。 结果 观察组患者总有效率为92.0%,对照组为76.0%,观察组患者总有效率高于对照组(P<0.05)。观察组治疗后患者促黄体生成素(LH)、睾酮(T)、INS、17-OHP、DHEA-S水平较治疗前下降,Cor水平较治疗前上升,且观察组患者治疗后LH、T、INS、17-OHP、DHEA-S水平低于对照组,Cor水平高于对照组,但血清卵泡刺激素(FSH)、雌二醇(E2)水平比较,差异无统计学意义(均P>0.05)。观察组患者妊娠率、排卵率高于对照组,但流产率比较,差异无统计学意义(P>0.05)。 结论 针灸治疗多囊卵巢综合征可改善患者的生殖内分泌代谢,促进排卵,提高妊娠率。Abstract: Objective To analyze the effect of acupuncture treatment on the levels of sex hormone, insulin, Cor, 17-hydroxyprogesterone (17-OHP), dehydroepiandrosterone sulfate (DHEA-S) and pregnancy rate, ovulation rate and abortion rate in patients with polycystic ovary syndrome. Methods A total of 100 cases of patients with polycystic ovary syndrome were selected in the Affiliated Hospital of Ningbo University Medical College treated from August 2016 to September 2017 and divided into 2 groups, with 50 cases in each group. The control group was treated by routine therapy, with oral progestin after withdrawing medicinal bleeding caused by 5 d oral clomifene citrate, 1 time/d. On the basis of conventional treatment, the observation group patients were given acupuncture treatment, mainly involving chung chi, uterus, Shenyu plus Xuehai points, such as acupuncture needling nourishing flat after catharsis, retaining needle for 30 min, 10 min a row needle, electrochemical luminescence to test sex hormones, INS, Cor, 17-OHP, DHEA-s level, pregnancy rate, ovulation rate and abortion rate. Results The total effective rate of the observation group was 92.0%, and that of the control group was 76.0%. The total effective rate of the observation group was higher than that of the control group (P<0.05).After treatment, luteinizing hormone (LH), testosterone (T), INS, 17-OHP,DHEA-s level in the observation group decreased compared with those before treatment, and Cor level increased compared with that before treatment. After treatment, LH, T, INS, 17-OHP and DHEA-17 level in the observation group were lower than those in the control group, and Cor level was higher than that in the control group. However, the difference in serum follicle-stimulating hormone (FSH) and estradiol (E2) level was not statistically significant (all P>0.05).The pregnancy rate of the observation group was higher than that of the control group, but the abortion rate was not statistically significant (P>0.05). Conclusion Acupuncture on polycystic ovary syndrome improves reproductive endocrine, ovulation and rate of pregnancy.
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Key words:
- Acupuncture /
- Polycystic ovary syndrome /
- Curative effect /
- Sex hormones
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