Abstract: Objective To analyze the effects of immunosuppressive agents combined with biological agents on nutritional status and inflammatory factors in patients with inflammatory bowel disease. Methods Seventy-two patients with inflammatory bowel disease in our hospital from January to December 2018 were selected. According to different therapies, 36 patients in the control group and 36 patients in the observation group were included. The control group was treated with azathioprine, an immunosuppressant, and the observation group was treated with azathioprine combined with infliximab, a biological agent. The clinical efficacy, nutritional status, inflammatory factors and adverse reactions of the two groups were compared. Results The total effective rate of the observation group (94.4%) was higher than that of the control group (77.8%). After treatment, the serum albumin, transferrin, prealbumin and hemoglobin in the observation group [(42.1±5.0)g/L, (2.8±0.5)g/L, (251.7±51.3)mg/L, (133.5±19.5)g/L] were better than those in the control group [(36.9±5.2)g/L, (2.5±0.3)g/L, (232.4±44.8)mg/L, (120.4±10.7)g/L], TNF-alpha, IL-4, IL-10, IL-17 in the observation group [(117.3±19.0)pg/L, (11.0±1.8)pg/L, (7.4±1.1)pg/L, (187.3±38.2)pg/L] was superior to the control group [(186.6±38.3)pg/L, (16.5±2.4)pg/L, (10.9±1.7)pg/L, (285.4±32.7)pg/L]. There were significant differences among the groups (all P<0.05). The incidence of adverse reactions in the observation group (16.7%) was similar to that in the control group (13.9%). There was no significant difference between the two groups (P>0.05). Conclusion Immunosuppressive agents combined with biological agents are effective in the treatment of inflammatory bowel disease, which can significantly improve the nutritional status of patients and reduce the level of inflammatory factors, and high safety.