Abstract: Objective To strengthen the understanding of the treatment of infective endocarditis, andprovide a theoretical basis for improving the level of diagnosis and treatment of infective endocarditis by retrospective analysis of pre-infection symptoms, pathogen detection and antibiotic treatment in patients with infective endocarditis. Methods The 173 cases of infective endocarditis patients admitted to our hospital from January 2013 to December 2017, according to the Diagnostic Criteria of Infectious Endocarditis of the Chinese Medical Association,were reviewed.Sexual analysis of clinical features of patients with infective endocarditis(general information, pre-infection, pathogen detection results, underlying diseases and susceptibility factors) and antibiotic treatment. Results Among 173 patients with infective endocarditis, the incidence rate of males was higher than that of females. The average age of onset was (9.13±3.19) years old, and the average length of hospital stay was (8.41±1.23) days. Among them, 75 cases (43.35%) had obvious symptoms of prodromal infection, mainly pulmonary infection (33.53%), and some cases had two infections. A total of 113 cases(65.32%) were positive for blood culture. A total of 118 pathogens were cultured. The highest proportion of streptococci was 60 (50.85%), 37 strains of Staphylococcus (31.36%) and 4 strains of Gram-bacillus (3.39%), 8 strains of fungi (6.78%). Common antibiotics mainly include penicillin antibiotics, vancomycin antibiotics and cephalosporin antibiotics. The use rate of penicillin antibiotics has decreased year by year (from 82.71% to 54.21%), and the use rate of vancomycin antibiotics and cephalosporin antibiotics has increased year by year, rising from 53.66% and 49.54% to 89.15% and 74.63%, respectively. Conclusion The pre-infection symptoms of infective endocarditis are mainly pulmonary infections, streptococcus and staphylococcal infections, including Gram-bacillus and fungi. The use rate of penicillin antibiotics has been decreasing year by year, and the use rate of vancomycin antibiotics and cephalosporin antibiotics has increased year by year.