Abstract: Objective To study the intervention effect of humanized nursing on patients with severe venous thromboembolism. Methods Two hundred patients with venous thromboembolism treated in our hospital from March 2016 to March 2018 were selected and divided into routine nursing group and humanized nursing group by random number table method. The routine nursing group was intervened by routine nursing, while the humanized nursing group was intervened by humanized nursing. Heparin was selectively injected according to the expression level of D-dimer in the two groups. The quality of life and psychological status after nursing were evaluated, and nursing satisfaction was counted. Results The total effective rate of humanized nursing group after nursing intervention (87.00%) was significantly higher than that of routine nursing group (76.00%, P<0.05); the scores of quality of life items in humanized nursing group after nursing intervention were significantly higher than those in routine nursing group (P<0.05); the scores of SDS and SAS in humanized nursing group after nursing intervention were significantly lower than those in routine nursing group (P<0.05); The satisfaction of patients after nursing intervention was significantly higher than that of patients in routine nursing group (P<0.05). Conclusion Humanistic nursing can improve the clinical symptoms of patients with severe venous thromboembolism, and selective use of heparin for anticoagulant treatment after d-dimer detection can play a better antithrombotic effect, significantly improve the quality of life of patients and improve their adverse emotions.