Abstract: Objective To observe the application of CNP in OVCF patients with PKP operation. Methods From January 2015 to January 2017, 100 OVCF patients in the first people's hospital of Wenling city were randomly divided into two groups according to the random number table. The two groups were given PKP operation. The control group were given routine nursing treatment, while the study group were treated by CNP. The hospitalization, hospitalization costs, VAS score, complication, brittle fracture incidence during the study period, the excellent rate of ODI score, bone mineral density T value, self-care ability score, SAS, SDS, quality of life score and satisfaction rate were reviewed and compared in the two groups. Results The hospitalization [(6.13±1.49) d vs. (11.48±2.76) d], VAS score [(2.53±0.46) score vs. (6.48±1.09) score], hospitalization costs [(1.66±0.41) ten thousands yuan vs. (2.59±0.87) ten thousands yuan], SDS [(39.17±3.56) score vs. (50.86±4.92) score], SAS [(41.27±4.93) score vs. (52.93±5.67) score], complication (0.0% vs. 5.0%) in the research group were less than those in the control group, the excellent rate of ODI (92.0% vs. 62.0%)，T value(-2.57±0.53 vs. -3.18±0.68)，self-care ability score[(119.19±5.48) score vs. (92.62±4.98) score], the quality of life scores [(77.89±8.25) score vs. (58.06±9.41) score], satisfaction rate (94.0% vs. 68.0%) in the research group were higher than the control group. The differences were statistically significant (P<0.05). Conclusion The application of CNP in OVCF patients with PKP operation can reduce the hospital stay, hospitalization costs, complications, relieving pain, anxiety and depression, improving self-care ability and life quality.