Abstract: Objective To explore the application effect of high quality nursing intervention based on humanistic care for patients with digestive endoscopy. Methods A total of 200 patients who underwent diagnosis and treatment in the digestive endoscopy room of our hospital from February 2017 to August 2018 were enrolled. According to the random number table method, the patients were divided into observation group and control group, with 100 cases in each group. The patients in the control group were treated with routine care, and the observation group was based on the quality control intervention based on human care. The nursing efficiency of the two groups of patients included: psychological state score before and after nursing, incidence of adverse reactions, incidence of adverse care events and satisfaction of nursing. Results At admission, the psychological status scores (SAS, SDS scores) of the two groups were not statistically significant (P>0.05); 10 minutes before anesthesia, the psychological status scores of the observation group were significantly lower than the control group(P<0.05); The incidence of reaction was 4.0%, which was lower than that of the control group (13.0%, P<0.05). The incidence of nursing adverse events in the observation group was 3.0%, which was much lower than that of the control group (P<0.05). The nursing satisfaction of the observation group was 96.0%, higher than 84.0% of the control group (P<0.05). Conclusion The application of high-quality nursing based on humanistic care in patients with digestive endoscopy can effectively improve the quality of nursing, reduce the incidence of adverse reactions and nursing adverse events, alleviate patients' nervous and anxiety, and effectively improve nursing satisfaction, which is worthy of clinical application.